Multicentric Osteolysis Nodulosis Arthropathy Syndrome Simulating Juvenile Idiopathic Arthritis in an Adult Female: A Case Report and a Literature Review

Multicentric osteolysis, nodulosis, and arthropathy (MONA) syndrome is one of the rare genetic skeletal dysplasias, inherited as an autosomal recessive disorder, which predominantly involves carpal tarsal bones with characteristic osteolytic lesions can be misdiagnosed juvenile idiopathic arthritis or rheumatoid arthritis. MONA includes diseases involving two genes: matrix metalloproteinase 2 (MMP2) gene 14 (MMP14). Both genes are assumed to cause phenotype variants same disease. Older patients may manifest some arthritic features, especially in wrist, minute pathological fractures occur well. These inflammatory physicians might prescribe corticosteroid disease-modifying immunosuppressive agents. Therefore, should carefully evaluate dysplasia make a correct diagnosis avoid unnecessary pharmacological intervention. We report case adult female who came our facility for intensive rehabilitation program.